Juan Hidalgo Selected Research

zaprinast

1/2013	Metallothioneins I/II are involved in the neuroprotective effect of sildenafil in focal brain injury.
2/2010	Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Juan Hidalgo Research Topics

Disease

12	Inflammation (Inflammations) 12/2021 - 08/2002
11	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2020 - 05/2003
11	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 10/2006
11	Brain Injuries (Brain Injury) 01/2013 - 01/2002
10	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 10/2020 - 09/2002
10	Body Weight (Weight, Body) 01/2020 - 04/2002
9	Neuroinflammatory Diseases 11/2022 - 10/2006
8	Gliosis 11/2022 - 01/2002
6	Obesity 11/2020 - 09/2013
6	Multiple Sclerosis 01/2020 - 08/2009
5	Insulin Resistance 01/2020 - 08/2004
5	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2014 - 05/2008
3	Disease Progression 04/2024 - 01/2014
3	Amyloid Plaque 11/2019 - 10/2006
3	Weight Gain 10/2019 - 09/2013
3	Encephalitis (Encephalitis, Rasmussen) 10/2011 - 05/2003
3	Necrosis 09/2009 - 12/2005
2	Infections 01/2022 - 02/2008
2	Cognitive Dysfunction 04/2015 - 03/2012
2	Nervous System Diseases (Neurological Disorders) 03/2012 - 02/2005
2	Stroke (Strokes) 04/2011 - 09/2009
2	Type 2 Diabetes Mellitus (MODY) 12/2006 - 11/2005
1	Autoimmune Diseases (Autoimmune Disease) 04/2024
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 04/2024
1	Lupus Nephritis 04/2024
1	Leigh Disease (Leigh's Disease) 11/2022
1	Atherosclerosis 01/2022
1	Anhedonia 01/2021
1	Mental Disorders (Mental Disorder) 01/2021
1	Septic Shock (Toxic Shock Syndrome) 01/2021
1	Peritonitis 01/2021
1	Leukemia 12/2019
1	Graft vs Host Disease (Graft-Versus-Host Disease) 12/2019
1	Glucose Intolerance 10/2019
1	Hyperinsulinism (Hyperinsulinemia) 10/2019
1	Eosinophilia 01/2018
1	Glioblastoma (Glioblastoma Multiforme) 01/2018
1	Neoplasms (Cancer) 01/2018
1	Hypoxia (Hypoxemia) 01/2018
1	Asthma (Bronchial Asthma) 01/2018
1	Amyloidosis 01/2017
1	Carcinogenesis 09/2014
1	Clinical Deterioration 01/2014

Drug/Important Bio-Agent (IBA)

37	Interleukin-6 (Interleukin 6)IBA 11/2022 - 04/2002
18	CytokinesIBA 11/2022 - 04/2002
16	MetallothioneinIBA 01/2017 - 01/2002
8	Proteins (Proteins, Gene)FDA Link 11/2012 - 01/2002
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2009 - 04/2002
4	Neuroprotective AgentsIBA 01/2014 - 02/2010
4	AntioxidantsIBA 11/2012 - 11/2005
3	Glucose (Dextrose)FDA LinkGeneric 10/2019 - 09/2009
3	Peptides (Polypeptides)IBA 01/2019 - 04/2011
3	Myelin-Oligodendrocyte GlycoproteinIBA 01/2014 - 08/2009
3	Sildenafil Citrate (Viagra)FDA Link 01/2014 - 04/2011
2	Amyloid (Amyloid Fibrils)IBA 01/2020 - 11/2012
2	LeptinIBA 10/2019 - 01/2017
2	MetalsIBA 01/2017 - 01/2011
2	Protein Isoforms (Isoforms)IBA 02/2015 - 01/2002
2	InterleukinsIBA 09/2013 - 04/2013
2	zaprinastIBA 01/2013 - 02/2010
2	Cyclic GMPIBA 01/2013 - 02/2010
2	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2013 - 02/2010
2	Phosphodiesterase InhibitorsIBA 04/2011 - 02/2010
2	Glial Fibrillary Acidic ProteinIBA 02/2010 - 07/2004
2	Monoamine Oxidase (MAO)IBA 02/2009 - 06/2008
2	Type I Tumor Necrosis Factor ReceptorsIBA 09/2007 - 12/2005
2	Type II Tumor Necrosis Factor ReceptorsIBA 09/2007 - 12/2005
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 09/2007 - 12/2005
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2006 - 06/2003
1	AutoantibodiesIBA 04/2024
1	Versicans (Versican)IBA 01/2022
1	ProstaglandinsIBA 01/2021
1	Cyclooxygenase 1IBA 01/2021
1	mouse metallothionein-1IBA 01/2019
1	Immunoglobulin E (IgE)IBA 01/2018
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2018
1	Citrate (si)-Synthase (Synthase, Citrate)IBA 01/2017
1	TheobromineIBA 04/2015
1	EnzymesIBA 04/2015
1	Dopamine (Intropin)FDA LinkGeneric 04/2015
1	Acetylcholine (Acetylcholine Chloride)FDA Link 04/2015
1	Insulin (Novolin)FDA Link 02/2015
1	Plasminogen Activators (Plasminogen Activator)IBA 09/2014
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 09/2014
1	NeuropeptidesIBA 08/2014
1	CorticosteroneIBA 07/2014
1	GlucocorticoidsIBA 07/2014
1	Phosphodiesterase 5 InhibitorsIBA 01/2014
1	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 01/2014
1	Interleukin-18 (Interleukin 18)IBA 09/2013
1	LipidsIBA 09/2013
1	AMP-Activated Protein KinasesIBA 09/2013
1	Heavy MetalsIBA 11/2012
1	Carrier Proteins (Binding Protein)IBA 11/2012
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 03/2012
1	PolyphenolsIBA 03/2012
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2012
1	Oxypurinol (Oxipurinol)IBA 01/2012

Therapy/Procedure

3	Therapeutics 01/2012 - 02/2005
1	Stem Cell Transplantation 12/2019